Find a Supreme Court case that deals with Section 1983 violations Essay

Find a Supreme Court case that deals with Section 1983 violations. Research the case in some depth - Essay Example It provides a remedy for deprivation of rights, such that the plaintiff has to prove personal involvement of the defendant, the defendant’s nature and quality of available immunity and the factors that will influence the alleged wrong. Defenses for federal, local and state government are qualified immunity in Section 1983 lawsuits. Additionally, prosecutors, judges and security officers have absolute immunity in Section 1983 lawsuits. Bivens claims that there has to be personal liability acting under the â€Å"Color of Law†. This implies that the person has to be subjected to the cause and must prove that they were deprived of their rights (Lippman 473). A Supreme Court case regarding civil remedies is Darling v. State of Florida; which took place in the Supreme Court of Florida. This case involved an inmate (Darling) challenging the use of lethal injections administered in accordance with sections 27.702 and 945.10, under the Florida Statues (2007). Additionally, the inmate wanted the court to overlook the mentioned sections and mentioned that Capital Collateral Regional Counsel Attorneys could not legally aid capital perpetrators like himself in challenging the execution method under Section 1983. The ruling rejected Darling’s claims but agreed with the claim regarding legal aid; by that permitting attorneys to file section 1983 for their capital defendant clients only of they are challenging the execution method. Clearly this case offered Capital Collateral Regional Counsel Attorneys representing capital defendants’ immunity as per section 1983. True to Bivens’ words, Darling had to prove he was deprived of h is civil rights. This he did by claiming that lethal injection method of execution is an unconstitutional and cruel punishment. This case opened the door for the capital defendant immunity as per section 1983; thereby gaining defense from post-conviction motions. In the light of the supreme law, the Appellee (state of Florida) acted within

MM416 Essay Example | Topics and Well Written Essays - 500 words

MM416 - Essay Example Strategic management accounting has not been described in a justifiable way in order to eliminate any doubts of reflection in the management accounting textbooks (Hoffjan & WÃ ¶mpener , 2006). Therefore, the lack of use vastly recognized understanding is associated to the reluctance of the textbook authors in the usage of "strategic management accounting." There are different ways through which Chief Financial Officers (CFOs) determine management accounting innovation in an organization. According to David Naranjo-Gil, innovation in management accounting is referred to practices, and ideas that are viewed as new in its adoption in improving organizational efficiency and performance (Naranjo-Gil , Maas , & Hartmann , 2008). Therefore, CFOs determine and ensure the adoption of these practices by assessing and reporting the required financial and non-financial information in making concrete organizational decisions. The individual variances between CFOs and their respective characteristics dictate the use of organizational innovation in management accounting. According to a dissemination study on management accounting, most public sectors adoption of management accounting innovations is significantly affected by the central government. As a result, the determination of management accounting innovation by CFOs is based on various politica l and economic factors. Strategic planning process is a core element in improving organizational efficiency and business operations. According to Gonn K. Weide, there are a vast range characteristic of strategic planning process that can be adopted by the management in accomplishing short-term and long-term organizational goals. For instance, an effective strategic planning must incorporate communication strategy, a task force, vision and mission statement, values, goals and objectives, activities, an implementation strategy, and a

Designing Compensation Systems and Employee Benefits Research Paper

Designing Compensation Systems and Employee Benefits - Research Paper Example Therefore, job evaluation attempts to document the shared and general characteristics of a job. Hence, in a job of driving a car, job evaluation would be attempting to determine the proficiency of the driver in driving the car or how well the person is aware of the roads. Job evaluation thus determines how well a person is handling each of the constituent tasks of the job. Employees receive compensation from companies for their work, however there’s a difference between compensation and pay. Compensation basically includes all types of financial rewards and tangible services which the company provides to the employees. For making the compensation internally consistent, the employees must be convinced that the jobs are being paid for by the employer according to its worth. There are certain jobs within the company which have more scope for contributing to the overall welfare of the company than other jobs. Hence such jobs are the ones which receive a higher pay. For example, in a hospital, the nurses are the ones who contribute greatly to the care of patients; hence the nurses are paid more than the orderlies. Determining the value of each and every job in an organization is very important since it assists in making the pay rates of an organization internally consistent. This value determination of jobs is called job evaluation. Some criteria used for job evaluation include the effort required to perform a job and the difficulty of a particular job. Compensations should also be developed which are market competitive. If for example the pay is low compared to the market, the company would encounter turnover and recruitment problems. If the pay is higher than the market, the company would potentially experience problems with the budget which may result in layoffs. The companies which pay above the market are termed as market leaders while the companies paying below the market rates are

Work Sheet Questions Essay Example for Free

Work Sheet Questions Essay 1) Throughout the selection, Jamaica Kinkaid seems to not be dealing with conflict in the present but more with reflecting on her conflicts in the past. She portrays her mother in not the best sense, sharing with us how she would always talk down to her kids and never be â€Å"motherly†. Kinkaid states when her and her siblings were younger, the mother was viewed as more of a â€Å"God† than a mother, that she was always there to help them out in times of need but as they started to grow, the mothers outlook on her children would change. The kids started to resent their mother to a point where Kinkaid said she would â€Å"rather be dead than spend an eternity to with her†. Kinkaid was left on bad terms with her mother, 3 years with no speaking because her mother never supported her responsibilities and didn’t consider Kinkaid becoming an independent woman. 2) At the time of the conflict, which is when Kinkaid had started to grow up, I could tell that she was very hurt by it. She says how she has children now and they love one another and love her, and she relates it back to her growing up and how everything was so much different with her relationship with her mother. When Kinkaid’s mother was acting the way she was towards herself and her siblings, she had a sense of resentment towards her mother because all her mother would do is discourage and lower her self esteem by all the negative comments being said. There was a sense of tension between the mother and her children, her children (to me) always seemed like they were unhappy by their mothers actions and the way she acted towards them. A mother is suppose to be the best person in your life, a care taker, some one always there to pick you up but, not in the case we are given with Jamaica Kinkaid. 3) When dealing with â€Å"initial perspective†, I decide to always culturally analyze the essay and what is going on throughout it. I noticed that at the beginning of the essay, Kinkaid is referring to her mother as a â€Å"God†, using the word god as a term to her your mother, made me take a religious look on some parts of the essay. When Kinkaid tries to explain to us how her mother is a â€Å"God†, I can’t help but stop myself and think â€Å"she is just explaining what normal mothers do†. I believe she perceived her mother as a God whenever she helped her kids and was there for them and when she wasn’t she was just a â€Å"mother†. I think the author holds her perspective of hurt throughout the essay because she is trying to share with her audience the way she felt and was treated throughout all the times with her mother. 4) Different perspectives exist in the same time period because there are millions of people living in the same time period and everyone is entitled to their own thought. Take slavery for example, in the South there were white people and black people. The black people hated slavery because they were the slaves and were being mistreated doing labor, where as the white people just controlled them. That is the same time period but two different perspectives. 5) There is no perspective change over time. Jamaica Kinkaid starts off the essay by telling us her problem with her mother, as the essay goes on she elaborates and tells us details leading up to all the problems, such as the issues with her brother and not knowing her real father. And she ends the story with speaking about her children and referring briefly back to why things never worked out with her mother. 6) I don’t believe there was a perspective time because as I said, Kinkaid stuck with the same theory throughout the essay. There was never a time in the essay where she had a total change of heart about her mother, there were times when she did talk good about her, when she would tell stories how her mother would take care of the kids when ever something was wrong, but mostly the story talks about the dislike and misunderstanding between a mother and her children.

Love, Death and the Changing of the Seasons Essay Example for Free

Love, Death and the Changing of the Seasons Essay The majority of poems and sonnets we have read, starting back from the first sonnet to today’s modern writers. They can be said to describe as a moment’s monument. As they describe a time of hurt, happiness or a memory in that was once enjoyed that has been put into words. I am going to discuss the meaning behind, what a moment’s monument is. I am also going to find out between two sonnets, The Forge and Love deaths and the changing of the season. Weather they answer the question â€Å"the sonnet has been described as a moment’s monument’. What is the meaning of a moment, it can mean so many things. Mainly it is described as a setting to a time in someone’s life. A moment in time that has been remembered, it could be happy, sad moment or an event that you have remember such a wedding day. Putting it into a sonnet, it can be a moment of a lost one someone is explaining. A monument is a statue, gravestone or a piece of history that can act as a record or memory for someone. For an example a gravestone is a record of a person’s death and the time they spent alive, it’s their record for people who loved them and also a way of saying â€Å"I was here. The sonnet Love deaths and the changing of the season by Marilyn Hacker can be described as a moment’s monument. The speaker of the sonnet is speaking about herself and about a moment in her life. The moment in her life that she is talking about is her loss of a lover. She is explaining the pain she has to face with letting go. The monument is the record of the tears she cried over her loss of this lover who was once there with her. This is shown in line thirteen and fourteen when she says â€Å"I drank our one year out in brine instead of honey. These lines mean she is describing the one year as drinking brine which is salt water which would cause dehydration and then sickness and eventually death, she has nothing left. When she compares brine to honey it is showing us, her life has gone from something sweet like honey, to something bitter like brine. The monument which can also be linked in this sonnet is that the death of the lover, will give them a gravestone as the record. The structure of the sonnet consists of fourteen line . The rhyme pattern can be debated of being either an Italian sonnet which the pattern the lines are divided into eight and six or English/Shakespearean which consists of the lines of three quatrains and two couplets. If it is an Italian version sonnet can be broken down the first eight lines. The first eight lines are her explaining her wanting him back. Then lines nine to fourteen is her accepting his gone and letting him go. If it is an English version sonnet it can be read as line one to four is her pain. Line five to eight is he realizing his not coming back and line nine to fourteen is her bitterness of crying over her loss. Hacker’s sonnet also allows the reader to get a language image. Some examples of this is, when she says â€Å"flood gates. † This is meaning that she is opening up her heart and letting the grief pouring out. She also says of a â€Å"gift† he left her behind, which is her way of saying bitterly he has left her with nothing but tears. Another language image is â€Å"season,† also mentioned as part of the title and mentioned in the sonnet. This can be used as she also mentions in the sonnet â€Å"winter,† which is a cold and comfortless and empty season, meaning this is how she feels with only have memories now. The metre of the poem is the standard iambic pentameter, but it is used to a good strong effect for the read as it emphasizes the main words such as in line three â€Å"stomach ache, headache and heartache, which is a good effect. As is emphasizes on the main word ache, which is another word for pain. The sonnet The Forge by Seamus Heaney can be described as a moment’s monument. The speaker in the sonnet is speaking from observation, watching the Black smith it could be someone who regularly passes by or an apprentice working with the blacksmith. The moment in time which the person watching is describing is the Blacksmith in the Forge and his every day routine of making horse shoes. This is shown in line nine when it is said â€Å"where he expends himself in shape and music†, we know this as he references to the guy as ‘he’ not ‘I’. The monument within this sonnet could also be considered a moment the lines twelve and thirteen shows a good example when it says â€Å"recalls a clatter of hoofs where traffic is flashing in rows. Demonstrating it’s a memory that a moment in time that he recorded of when the streets where once surrounded with horse and remembering the sound of their shoes clattering on the roads, but now it is taken over by car and traffic lights. The structure of the sonnet is a fourteen line sonnet. The rhyme pattern of this sonnet is an Italian sonnet. The Italian sonnets are in the pattern of lines that are divided into eight and six. It can be put lines one to eight is the person watching the daily routine completed by the Blacksmith and him going about his everyday activities. Then line nine to fourteen is the person watching the Blacksmith reminisce on the past and then getting upset and returning to his work. The poem is the normal iambic pentameter, but it is used responsively, for a good outcome. For example in the very first line we already get words like dark, which is a powerful word on its own Both The Forge and Love, Death and the changing of the seasons are sonnets that are a moment’s monument. The both describe a moment in time. Weather it is a loss of a lover or a working day. They both describe a monument a memory, traffic replacing horses or the way he use to take her in his arms.

Gene Expression of Mitochondrial Enzymes from Exercise

Gene Expression of Mitochondrial Enzymes from Exercise Induced Change in Gene Expression of Mitochondrial Enzymes as a Result of Intense Exercise Abstract Exercise-induced changes in gene expression of mitochondrial enzymes has become a leading target for sports medicine research. Previous indirect testing of delayed-onset muscle soreness and changes in rotation of motion do not provide a sufficient explanation of the induced changes to the genome (Hubal, et al., 2010). Biomarker testing has allowed for detecting levels of proteins within a sample. Blood and serum levels, taken before and after exercise, have been analyzed and tested for changes in protein activity. Calf-raises show an increase in creatine kinase (CK) and aldolase (ALD) activities (Kanda, et al., 2014). MicroRNA arrays along with telomere extension mRNA arrays and quantitative real-time PCR on RNA taken from white blood cells have shown to down-regulate telomeric repeat binding factor 2 (Chilton, et al., 2014). Biochemical testing at the genomic level will provide a better understanding of the long-term effects of intense exercise. Knowing these high-intensity induced gene expressions in mitochondrial DNA aids in knowing what causes diseases such as Rhabdomyolysis. Introduction Centuries ago staying physically fit was accentual to stay alive. Those that were not fit were not able to kill prey and therefore would be less likely to survive. In today’s world, being physically fit is not a necessity, but rather something that many people strive for to live a healthy lifestyle. Living an active life lowers the chance of many diseases, such as kidney and Alzheimer’s, and cancers, such as colon and breast. It is therefore crucial to understand the biochemistry behind exercise as a helpful preventative measure for health problems. When exercising, the body is put through tasks that disrupt homeostasis. The body wants to eliminate wide spread deviants of homeostasis. However, after and during exercise the body needs more oxygen and energy to be able to complete the tasks one is putting on the body. These demands, the increase in affinity for oxygen and energy, require metabolic responses that disrupt homeostasis. To test these metabolic responses, many scientists use biomarker testing on whole blood and serum samples rather than pieces of skeletal muscle. Biomarkers are used to measure the presence of a physiological state. These markers have biological properties that measure the blood and serum. There are many different changes in the mitochondrial genome during and immediately following exercise. This paper will focus on an overview of some endurance training biomarkers, but will mainly focus on high intensity exercise and the induced gene expression in the mitochondrial genome. It is important to study the effects of exercise on gene expression to know at what levels of various genes, like lactate dehydrogenase, aldose, etc., come dangerous to human health as to prevention diseases such as Rhadomyolysis (Heled, et al., 2005). Proliferator-activated Receptors association with Exercise-Induced Mitochondrial Biogenesis Transcriptional cofactors peroxisome proliferator-activated receptors (PGC) regulate gene expression (Lin, et al., 2005). PGC-1a regulates gene expression in the mitochondrial genome. This coactivator interacts with other proteins to regulate contraction. Overexpression of PGC-1a results in an increase in mitochondrial gene function (Lin, et al., 2002). Calcium/Calmodulin-dependent kinase 2 (CaMKII), AMP-activated protein kinase (AMPK), and nitrogen-activated protein kinases (MAPKs) all have important signaling that help regulate PGC-1a (Hawley, et al., 2010). Calcium is important for energy due to its role in the sarcoplasmic reticulum. Contractions of skeletal muscle are dependent on high levels of calcium. The calcium then binds to troponin, which moves the myosin fibers resulting in muscle contractions. Calcium also plays a major role in calcium-calmodulin-dependent kinases. Calcium/Calmodulin-dependent kinase 2 (CaMKII) activation increases the transport of glucose in skeletal muscle (Rose, A. and Hargreaves, M., 2003). AMPK and MAPks activate PGC-1a, Figure 1, by phosphorylating transcription factors myocyte enhancer factor 2 and ATF-2, respectively (McGee and Hargreaves, 2010). Figure 1. Schematic of the Major Signaling Pathways Involved in the Control of Skeletal Muscle Hypertrophy and Mitochondrial Biogenesis (Hawley, et al., 2010). The right side of this figure shows the correlation of the AMPK, CAMK, SIRT1, MAPK pathways that effect PGC-1a which regulates mitochondrial biogenesis. Another inhibitor of PGC-1a is a deactelyase silent mating type-information regulation 2 homolg 1 (SIRT1) (HIgashida, et al., 2013). Since SIRT1 is NADà ¢Ã‚ Ã‚ º-dependent, Figure 1, changes in concentration of NADà ¢Ã‚ Ã‚ º change the SIRT1 activity in the cell (Gurd, 2011). Many studies have shown that the protein content of SIRT1 and the activity are independent, and that because of that it is thought that the SIRT1 activity is what subsidizes to PGC-1a activity (Gurd 2011). Test For Correlation between SIRT1 and PGC-1a. The following experiment was performed by Chabi and coworkers to examine SIRT1’s role in muscle during muscle use (Chabi, et al., 2009). Rats were placed into a control group and a running group. The running group were able to run on a loaded wheel. Weight was added to the wheel during weeks one through four, but maintained a 200 g weight from weeks five through eight. The plantaris (PL) and soleus (SOL) muscles were taken as well as the tibialis anterior (TA) and extensor digitorum longus (EDL) for analysis. Once the proteins were extracted, the SIRT1 activity and deacetylase was found by fluorescence. A cycling assay was used to determine the NAD nucleotides. Immunoblotting was done to test expression of PGC-1a, cytochrome c, SIRT1 and GAPDH. SIRT1 expression showed to be the highest in the liver and slow-twitch muscle while PGC-1a immunoreactivity was highest in the heart muscle. This experiment did not show a correlation between SIRT1 and PGC-1a expression, like the scientists hoped, but it did bring up the question if SIRT1 activity is altered by acute exercise instead of high-intensity. Eccentric Exercise and Muscle Damage Markers The following was performed by Kazue Kanda and coworkers to see if eccentric exercise affects muscle damage markers (Kanda, et al., 2014). Participates in this study each performed right calf-raises on a force plate to add 0.5 Hz to each lift. With 3 min for rest, forty repetitions for 10 sets were completed with half of their weight along with the added force. Immediately following these muscle contractions, the medial and lateral gastrocnemius and soleus were measured for tenderness using a FP meter. The meter rated based on a visual analogue scale from no pain to extremely sore. The ankle was tested for range of motion (ROM) along the dosiflexion position (-20 ) to the plantar flexion position (15). Both of tenderness of the calf and the ROM was tested at 24 h increments until 168 h after the repetitive muscle contractions. After 72 h the tenderness of the right calf increased significantly (p Subsequently, samples from the blood and urine were taken both before and at various times after the exercise. Various proteins, creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), aldolase (ALD) and alanine aminotransferase (ALT) were tested from the serum. An Enzyme-linked immunosorbent assay (ELISA) was used to test for fatty acid-binding proteins (FABP). The activities of CK and AST increased significantly post 72 h. The activities of ALT and ALD also increased for each sample, however, it was not significant. LDH activity had a significant increase at 96 h after exercise, but not really before. The results for ALD did correlate with the tenderness of the medial gastrocnemius at the 72 h mark and could suggest that ALD might be a better muscle damage indicator because the other proteins tested did not correlate with tenderness. The ELISA testing on FABP resulted in no detectable changes. This experiment used two methods of testing muscle damage and had correlated results for ALD. Exercise-Induced biochemical changes in Quadriceps and Gastrocnemius in Mice The following was performed by L. Toti and coworkers to see the changes in blood lactate as well as mitochondrial enzymes as a result of two different exercises; intense activity with recovery periods and moderate activity with no recovery periods (Toti, et al., 2013). Immunoblotting and immunohistochemistry were used to assess the two muscle groups, the quadriceps and gastrocnemius, to see expression of enzymes correlated with oxidative metabolism. Mice were divided into three different groups based on similar maximal velocities. Mice with higher maximal velocities partaked in the intense activity: running at 90% for 2 min followed by 1 min of recovery. The mice with lower mamximal velocities partaked in continuous running at 60% velocity. Data was collected for 40 sessions, where each mouse ran a distance of 1000 meters. Blood samples were taken at sessions 1, 20 and 40. Blood lactate was tested and showed a decrease in both groups by session 40, with the higher-velocity group measuring significantly lower than the lower-velocity group. Immunochemistry testing resulted in an increase in response for the high-velocity mice for both the quadriceps and the gastrocnemius. This experiment showed that high-intensity training impacted the biochemistry more so than the low-velocity training. MicroRNA Expression and Telomere-Associated Genes After Acute Exercise The following was performed by W. Chilton and coworkers to see mechanisms the correlation between white blood cell (WBC) telomere length and exercise (Chiltion, et al., 2014). Participants in this study ran on a treadmill for 30 min at 80% of maximum oxygen uptake. Blood samples were taken before and immediately following the running as well as an hour post-running. MicroRNA expression arrays that could measure a whole genome, were used on the samples. TERT mRNA expression levels were then tested by qPCR. Telomerase reverse transcriptase (TERT) mRNA and Sirtuin-6 (SIRT6) were two of the genes tested. This experiment was able to show supporting evidence that the transcriptional regulation of key telomeric genes can be affected by exercise. TERT mRNA was upregulated as well as the SIRT6. The qPCR testing on TERT and SIRT6 showed the increase in binding miRNA. Chilton did express that the increases in both the SIRT6 and the TERT mRNAs could have been upregulations from the extra-telomeric pathways instead of just the telomeric roles since there was no definitive way to differentiate between the two in this experiment. It is important to understand exercise’s effects on telomeres and its corresponding proteins to gain an insight on how physical health improves telomere homeostasis, keeping the telomeres from getting too short and the cell dying. Chemokine Polymorphisms Association with Skeletal Muscle Damage The following experiment was performed by M. Hubal and coworkers to see if chemokine ligand 2 (CCL2) and chemokine receptor 2 (CCR 2) are associated with biomarkers after exercising (Hubal, et al., 2010). CCL2 is important because it recruits necessary items, such as memory T cells, dendritic cells, and monocytes, to inflammation sites in injured tissue. CCR2, the receptor molecule for CCL2, mediates with calcium mobilization. It is suggested that CCL2 and CCR3 play major roles in the repair of skeletal muscle damage. Participants performed two, 25 contractions, sets of elbow flexor muscle contractions in the non-dominant arm. It was crucial that the participants had constant maximal effort and stayed hydrated the 10 days following the exercise. Blood samples were taken and sent for genotyping. Single nucleotide polymorphisms (SNPs) known to influence the level of CCL2 proteins were analyzed using PCR. There were four SNPs from CCL2 and three from CCR2 that should high phenotype associations. The minor allele found in the SNPs was correlated with an increase in damage. This study was able to show that variations of the CCL2 and CCR2 genes are related to muscle damage markers caused by exercise. Molecular and Metabolic Changes of High-intensity Interval Training The following experiment was performed by J. Little and coworkers to assess the molecular and metabolic changes of high-intensity interval training (Little, et al., 2010). Participants performed six cycling training sessions over the course of two weeks. Each session consisted of approximately 30 min of high intensity intervals. By the last sessions, the subjects were completing 12 intervals of 60 s high-intensity cycling followed by 75 s low intensity for recovery. Biopsies from the leg were taken before and after the two week training. The muscle lysates were taken for Western blotting and enzyme activity testing. Western blotting was used to test for glucose transporter type 4 (GLUT4), PGC-1a, and SIRT1while the mitochondrial enzyme activity was tested on cytochrome c oxidase (COX). The subjects improved in both time and power, about 10%, for cycling during the two week training session. COX activity increased by 29%. PGC-1a increased by approximately 24%, however, the protein itself was did not have any genetic changes. GLUT4 content increased by 119%, while SIRT1 increased by approximately 56%. This experiment showed some changes, due to exercise, in regulators that are important in mitochondrial biogenesis. Conclusion There are many induced changes in the mitochondrial genome during and after exercise. These changes occur to help maintain cell homeostasis while the body is being put through stress during intense exercise. Blood and serum samples along with tissue extractions have provided a way to examine these changes and see how one is correlated with another (Figure 1). PGC-1a helps muscle contractions by regulating gene expression in mitochondria biogenesis. However, PGC-1a has many cofactors helping it. CaMKII, AMPK, and MAPKs all help in providing energy to the skeletal muscles by impacting the activation of PGC-1a. Although SIRT1 deactelyation inhibits PGC-1a, it still impacts the biochemistry of the body during workouts due to deactelyation. LDH activity was shown to increase hours after high-intensity exercise because LDH it is released as pyruvate is converted into lactate. ALD, which converts sugar into energy, was found to be a good indicator because in the calf-raises experiment the results from the biomarker testing as well as the tenderness testing correlated with each other. CCL2 and CCR2 were found to have changes in SNPs that corresponded to the high-intensity exercise and most likely aide in the recruiting of the memory T cells and dendritic cells to the injured tissue. High-intensity exercise, without time for recovery, would keep the body maintained at a stressful state of trying to bring it back to homeostasis. As proven in the calf-raise experiment, LDH levels decreased as the participants were able to come accustom to the exercises. The bodies were no longer in shock. If the bodies were did not become accustom, or the body was not given any time for recovery, the chances of obtaining diseases such as Rhabdomyolysis increases. Future experiments need to focus on what levels of these regulators will become dangerous. Research should be down to further understand the relationship between SIRT1 and PGC-1a. References Chabi, B., Adhihetty, P.J., O’Leary, M.F., Menzies, K.J., and Hood, D. (2009) Relationship between sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and diuse. J. Appl. Physiol. 107(6):1730-1735. Chilton, W., Marques, F., West, J., Kannourakis, G., Berzins, S., O’Briend, B., and Charchar, F. (2014) Acute Exercise Leads to Regulation of Telomere-Associated Genes and MicroRNA Expression in Immune Cells. PLoS ONE. 9, 1-13. Gurd, B. (2011) Deacetylation of PGC-1a by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. App. Physiol. Nutr. Metab. 36:589-597. Hawley, J., Hargreaves, M., Joyner, M., and Zierath, J. (2010) Integrative Biology of Exercise. Cell 159, 738-749. Heled., Y., Zarian., A., Moran., D., and Hadad, E. (2005) Exercise induced rhabdomyolysis – characteristics, mechanisms and treatment. Harefuah 144(1):34-8. Hubal, M., Devaney, J., Hoffman, E., Zambraski, E., Gordish-Dressman, H., Kerns, A., Larking, J., Adham, K., Patel, R., and Clarkson, P. (2010) CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J of App Physicol 108(6), 1651-1658. Kanda, K., Sugama, K., Sakuma, J., Kawakami, Y., and Suzuki, K. (2014) Evaluation of serum leaking enzymes and investigation into new biomarkers for exercise-induced muscle damage Exerc Immunol Rev. 20, 39-54. Lin, J., Wu, H., Tarr, P., Zhang, C., Wu, Z., Boss, O., Michael, L., Puigserver, P., Isotani, E., Olson, E., Lowell, B., Bassel-Duby, R., and Spiegelman, B. (2002). Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418, 797-801. Lin, J., Handschin, C., and Spiegelman, B. (2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell. Metab. 1, 361-370. Little, J.P., Safdar, A., Wilkin, G.P., Tarnopolsky, M.A., and Gibala, M.J. (2010) A practical model of low-volume high intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. J. Physiol. 588(6):1011-1022. McGee, S., Hargreaves, M. (2010). AMPK-mediated regulation of transcription in skeletal muscle. Clin. Sci. 118, 258-263. Rose, A.J., and Hargreaves, M. (2003). Exercise increases -calmodulin-dependent protein kinase II activity in human skeletal muscle. J. Physiol. 265, E380-E391. Toti, L., Bartalucci, A., Ferrucci, M., Fulceri, F., Lazzeri, G., Lenzi, P., Soldani, P., Gobbi, P., La Torre, A., and Gesi, M. (2013) High-intensity exercise training induces morphological and biochemical changes in skeletal muscles. Biol Sport 30(4), 301-309. Alissa Christian

Heineken out of Burma :: essays research papers

Heineken out of Burma The action groups 'A Seed Europe' and the Dutch action group 'XminY' started a campaign in February 1996, called "Heineken out of Burma!". The investment plans of the Dutch brewer Heineken Inc. in Burma (Myanmar), were said to provide material support and legitimacy to the violent dictatory rulers of the country. Heineken sees Burma as an emerging market, that must be entered without delay. Western beer markets are becoming saturated and the potentials for growth in Asia are enormous. Competitors, such as Carlsberg and San Miguel, are likewise turning their investments towards Asia. The political opposition in Burma, lead by Nobel Price laureate Aung San Suu Kyi, calls on foreign companies not to invest in Burma for the time being, however. International embargoes can support the internal opposition against the regime, she says. Heineken has a 42% share in the Asian Pacific Brewery Ltd (APBL). This, in turn, owns 60% of the shares of the Myanmar Brewery Ltd (MBL). The remaining 40% of the shares belong to UMEHL: the Union of Myanmar Economic Holdings Ltd. UMEHL is lead by the military rules of the country. APBL wants to invest 15 million US dollars in a brewery in Burma. That can only be done in the form of a joint-venture with UMEHL. The military rulers force this construction onto APBL. Forty percent of the profits that the brewery will yield in the future will thus flow towards the dictators. Heineken did not deny that the Burmese regime is guilty of gross violations of human rights. On the contrary, Heineken shared the analyses of the action groups and said to be very concerned about the human rights situation in Burma. There is one difference, however: the action groups concluded that Heineken should cancel its investments in Burma, but Heineken did not intend to do so. "We sincerely believe that we can reconcile our policy in Burma with our corporate values and norms", so Heineken's press officer before the Dutch media. The action groups say: "By investing in Burma at this moment, and by embarking on a joint venture with UMEHL, Heineken makes itself an accomplice in the tragedy of the Burmese people". This complicity consists in particular of two points.